Rib-X Pharmaceuticals, Inc. to Present at Cambridge Healthtech Institute's 2nd Annual Challenge of Antibacterial Development Conference
New Haven, Connecticut. April 22, 2008 — Rib-X Pharmaceuticals, Inc.,
a development stage company focused on the discovery and development of novel antibiotics
for the treatment of antibiotic-resistant infections, today announced that Graham Johnson, Ph.D.,
Chief Research Officer and Vice President, Discovery, will be presenting at the Cambridge
Healthtech Institute's 2nd Annual "The Challenge of Antibacterial Development" conference on
April 24, 2008 in San Diego, CA.
Dr. Johnson's presentation, entitled "Using Structure-Based Discovery to Define Novel Macrolide Antibiotics Targeting the 50S Ribosomal Subunit", will focus on Rib-X's ability to develop new antibiotic compounds using a drug discovery engine that combines a sophisticated, structure based drug design approach with computational analyses and proprietary knowledge of the high-resolution crystal structure of the bacterial ribosome. Rib-X's most advanced discovery program is focused on engineering novel macrolides that overcome multiple forms of bacterial resistance. This discovery program has produced several series of structurally-distinct compounds effective against a wide range of bacteria, including those generally associated with nosocomial Gram-positive infections, community respiratory-tract infections and uncomplicated skin and soft tissue infections (uSSTIs) seen both in the hospital and community settings. Three distinct compound families with drug-like properties are being advanced for Phase 1 studies to commence late in 2008. In his presentation, Dr. Johnson will highlight the Rib-X structure driven drug discovery approaches yielding this richness of novel, orally bioavailable macrolides.
About Rib-X Pharmaceuticals
Rib-X Pharmaceuticals, Inc. is a product-driven small-molecule drug discovery and development company focused on developing and commercializing antibiotics to treat highly-resistant bacterial infections. Based in New Haven, Connecticut, the Company has raised over $170 million and has two programs, delafloxacin and radezolid, in advanced clinical trials. In addition, a preclinical program featuring an entirely new class of broad-spectrum antibiotics with the potential to treat even highly- resistant Gram-negative infections is scheduled to begin clinical trials in 2011.
Rib-X designs and develops novel small-molecule antibiotics by leveraging the Company's Nobel Prize- winning discovery platform to perform structure-based design and optimization. While many commercially valuable classes of antibiotics bind to the bacterial ribosome, including oxazolidinones, tetracyclines and macrolides, traditional antibiotic discovery relies heavily on serendipity. Rib-X's key competitive advantage is its proprietary understanding of ribosome structure, which enables it to generate antibiotics that overcome known resistance mechanisms and have broad-spectrum activity.
Rib-X's integrated research strategy combines state-of-the-art, proprietary computational analysis, X-ray crystallography, medicinal chemistry, microbiology and biochemistry, thereby allowing Rib-X to rapidly synthesize new agents designed to avoid typical antibiotic resistance mechanisms. Rib-X's iterative intelligent engine has yielded several distinct new antibiotic classes.
Dr. Johnson's presentation, entitled "Using Structure-Based Discovery to Define Novel Macrolide Antibiotics Targeting the 50S Ribosomal Subunit", will focus on Rib-X's ability to develop new antibiotic compounds using a drug discovery engine that combines a sophisticated, structure based drug design approach with computational analyses and proprietary knowledge of the high-resolution crystal structure of the bacterial ribosome. Rib-X's most advanced discovery program is focused on engineering novel macrolides that overcome multiple forms of bacterial resistance. This discovery program has produced several series of structurally-distinct compounds effective against a wide range of bacteria, including those generally associated with nosocomial Gram-positive infections, community respiratory-tract infections and uncomplicated skin and soft tissue infections (uSSTIs) seen both in the hospital and community settings. Three distinct compound families with drug-like properties are being advanced for Phase 1 studies to commence late in 2008. In his presentation, Dr. Johnson will highlight the Rib-X structure driven drug discovery approaches yielding this richness of novel, orally bioavailable macrolides.
About Rib-X Pharmaceuticals
Rib-X Pharmaceuticals, Inc. is a product-driven small-molecule drug discovery and development company focused on developing and commercializing antibiotics to treat highly-resistant bacterial infections. Based in New Haven, Connecticut, the Company has raised over $170 million and has two programs, delafloxacin and radezolid, in advanced clinical trials. In addition, a preclinical program featuring an entirely new class of broad-spectrum antibiotics with the potential to treat even highly- resistant Gram-negative infections is scheduled to begin clinical trials in 2011.
Rib-X designs and develops novel small-molecule antibiotics by leveraging the Company's Nobel Prize- winning discovery platform to perform structure-based design and optimization. While many commercially valuable classes of antibiotics bind to the bacterial ribosome, including oxazolidinones, tetracyclines and macrolides, traditional antibiotic discovery relies heavily on serendipity. Rib-X's key competitive advantage is its proprietary understanding of ribosome structure, which enables it to generate antibiotics that overcome known resistance mechanisms and have broad-spectrum activity.
Rib-X's integrated research strategy combines state-of-the-art, proprietary computational analysis, X-ray crystallography, medicinal chemistry, microbiology and biochemistry, thereby allowing Rib-X to rapidly synthesize new agents designed to avoid typical antibiotic resistance mechanisms. Rib-X's iterative intelligent engine has yielded several distinct new antibiotic classes.
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Kari Watson
MacDougall BioMedical Communications 781-235-3060 kari@macbiocom.com |
| Investor Relations |
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Sarah Cavanaugh
MacDougall BioMedical Communications 781-235-3060 scavanaugh@macbiocom.com |